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Prof. Niels Tommerup

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Lars Hansen

Lars Hansen

Research assistant / Forskningsassistent

Cloning and characterization of homeobox genes. Bioinfromatics. Eye development and genetics. Mutation screening of cataract genes, Mutation identification in the Wolfram gene in association with Wolfram Syndrome, hearing loss and psychriatic diseases. Oligodontia/hypodontia, tooth development and mutation screenin in PAX9, MSX1 and AXIN2. RUNX2 – mutation identification in the RUNX2 gene In association with cleidocranial dysplasia. Collaboration with Copenhagen Family Bank. Supervision of master and Ph.D. students Teaching.


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Publications related to WJC

29.   Hansen L, Tawamie H, Murakami Y, Mang Y, ur Rehman S, Buchert R, Schaffer S, Muhammad S, Bak M, Nöthen MM, Bennett E, Maeda Y, Aigner M, Reis A, Kinoshita T, Kinoshita T, Tommerup N, Baig SM, Jamra RA. Hypomorphic Mutations in PGAP2, Encoding a GPI-Anchor-Remodeling Protein, Cause Autosomal-Recessive Intellectual Disability. Am J Hum Genet. 2013;92(4):575-83.
28.   Jakobsen LP, Pfeiffer P, Andersen M, Eiberg H, Hansen L, Mang Y, Bak M, Møller RS, Klitten LL, Tommerup N. Genetic studies in congenital anterior midline cervical cleft. Am J Med Genet A. 2012;158A:2021-6.
27.   Hussain MS, Bakhtiar SM, Farooq M, Anjum I, Janzen E, Toliat MR, Eiberg H, Kjaer KW, Tommerup N, Noegel AA, Nürnberg P, Baig SM, Hansen L. Genetic heterogeneity in Pakistani microcephaly families. Clin Genet. 2012 Jul 6;9999(999A). doi: 10.1111/j.1399-0004.2012.01932.x. [Epub ahead of print].
26.   Rehman SU, Baig SM, Eiberg H, Rehman SU, Ahmad I, Malik NA, Tommerup N, Hansen L. Autozygosity mapping of a large consanguineous Pakistani family reveals a novel non-syndromic autosomal recessive mental retardation locus on 11p15-tel. Neurogenetics. 2011;12:247-51.
25.   Rendtorff ND, Lodahl M, Boulahbel H, Johansen IR, Pandya A, Welch KO, Norris VW, Arnos KS, Bitner-Glindzicz M, Emery SB, Mets MB, Fagerheim T, Eriksson K, Hansen L, Bruhn H, Möller C, Lindholm S, Ensgaard S, Lesperance MM, Tranebjaerg L. Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. Am J Med Genet A. 2011;155A:1298-313.
24.   Hansen L, Riis AK, Silahtaropglu A, Hove H, Lauridsen E, Eiberg H, Kreiborg S. RUNX2 analysis of Danish cleidocranial dysplasia families. Clin Genet 2011:79:254-263.
23.   Jakobsen LP, Bugge M, Ullmann R, Schjerling CK, Borup R, Hansen L, Eiberg H, Tommerup N. 500K SNP array analyses in blood and saliva showed no differences in a pair of monozygotic twins discordant for cleft lip. Am J Med Genet A. 2011;155A:652-5.
22.   Anjum I, Eiberg H, Baig SM, Tommerup N, Hansen L. A mutation in the FOXE3 gene causes congenital primary aphakia in an autosomal recessive consanguineous Pakistani family. Mol Vis. 2010 ;16:549-55.
21.   Farooq M, Troelsen JT, Boyd M, Eiberg H, Hansen L, Hussain MS, Rehman SU, Azhar A, Ali A, Bakhtiar SM, Tommerup N, Baig SM, Kjaer KW. Preaxial polydactyly/triphalangeal thumb is associated with changed transcription factor-binding affinity in a family with a novel point mutation in the long-range cis-regulatory element ZRS. Eur J Hum Genet. 2010;18:733-6.
20.   Hansen L, Mikkelsen A, Nürnberg P, Nürnberg G, Anjum I, Eiberg H, Rosenberg T. Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract. Invest Ophthalmol Vis Sci. 2009; 50:3291-3303.
19.   Muhammad F, Mahmood Baig S, Hansen L, Sajid Hussain M, Anjum Inayat I, Aslam M, Anver Qureshi J, Toilat M, Kirst E, Wajid M, Nürnberg P, Eiberg H, Tommerup N, Kjaer KW. Compound heterozygous ASPM mutations in Pakistani MCPH families. Am J Med Genet A. 2009;149:926-30.
18.   de Medeiros F, Hansen L, Mawlad E, Eiberg H, Asklund C, Tommerup N, Jakobsen LP. A novel mutation in IRF6 resulting in VWS-PPS spectrum disorder with renal aplasia. Am J Med Genet A. 2008;146:1605-8.
17.   Eiberg H, Troelsen J, Nielsen M, Mikkelsen A, Mengel-From J, Kjaer KW, Hansen L. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression. Hum Genet. 2008;123:177-87.
16.   Wissinger B, Dangel S, Jägle H, Hansen L, Baumann B, Rudolph G, Wolf C, Bonin M, Koeppen K, Ladewig T, Kohl S, Zrenner E, Rosenberg T. Cone dystrophy with supernormal rod response is strictly associated with mutations in KCNV2. Invest Ophthalmol Vis Sci. 2008;49:751-7.
15.   Hansen L, Eiberg H, Rosenberg T. Novel MAF mutation in a family with congenital cataract-microcornea syndrome. Mol Vis. 2007;13:2019-22.
14.   Hansen L, Yao W, Eiberg H, Kjaer KW, Baggesen K, Hejtmancik JF, Rosenberg T. Genetic Heterogeneity in Microcornea-Cataract: Five Novel Mutations in CRYAA, CRYGD, and GJA8. Invest Ophthalmol Vis Sci. 2007;48:3937-44.
13.   Hansen L, Kreiborg S, Jarlov H, Niebuhr E, Eiberg H. A novel nonsense mutation in PAX9 is associated with marked variability in number of missing teeth. Eur J Oral Sci 2007;115:1–4.
12.   Hansen L, Yao W, Eiberg H, Funding M, Riise R, Kjaer KW, Hejtmancik JF, Rosenberg T. The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46. Mol Vis. 2006;12:1033-9.
11.   Eiberg H, Hansen L, Kjer B, Hansen T, Pedersen O, Bille M, Rosenberg T, Tranebjaerg L. Autosomal dominant optic atrophy associated with hearing impairment and impaired glucose regulation caused by a missense mutation in the WFS1 gene. J Med Genet. 2006;43:435-40.
10.   Wu Q, Tommerup N, Ming Wang S, Hansen L. A novel primate specific gene, CEI, is located in the homeobox gene IRXA2 promoter in Homo sapiens. Gene. 2006;371:167-73.
9.   Kjaer KW, Eiberg H, Hansen L, van der Hagen CB, Rosendahl K, Tommerup N, Mundlos S. A mutation in the receptor binding site of GDF5 causes Mohr-Wriedt brachydactyly type A2. J Med Genet. 2006;43:225-31.
8.   Hansen L, Eiberg H, Barrett T, Bek T, Kjaersgaard P, Tranebjaerg L, Rosenberg T. Mutation analysis of the WFS1 gene in seven Danish Wolfram syndrome families; four new mutations identified. Eur J Hum Genet. 2005;13:1275-84.
7.   Kjaer KW, Hansen L, Eiberg H, Utkus A, Skovgaard LT, Leicht P, Opitz JM, Tommerup N. A 72-year-old Danish puzzle resolved-comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions. Am J Med Genet A. 2005;138:328-39.
6.   Kjaer KW, Hansen L, Eiberg H, Christensen KS, Opitz JM, Tommerup N. Male-to-male transmission in Laurin-Sandrow syndrome and exclusion of RARB and RARG. Am J Med Genet A. 2005;137:148-52.
5.   Wu Q, Niebuhr E, Yang H, Hansen L. Determination of the critical region for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR. Eur J Hum Genet. 2005;13:475-85.
4.   Eiberg H, Hansen L, Hansen C, Mohr J, Teglbjaerg PS, Kjaer KW. Mapping of hereditary trichilemmal cyst (TRICY1) to chromosome 3p24-p21.2 and exclusion of beta-CATENIN and MLH1. Am J Med Genet A. 2005;133:44-7.
3.   Kjaer KW, Hansen L, Schwabe GC, Marques-de-Faria AP, Eiberg H, Mundlos S, Tommerup N, Rosenberg T. Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome). J Med Genet. 2005;42:292-8.
2.   Bak M, Hansen C, Henriksen KF, Hansen L, Pakkenberg H, Eiberg H, Tommerup N. Mutation analysis of the Sonic hedgehog promoter and putative enhancer elements in Parkinsons disease patients. Brain Res Mol Brain Res. 2004;126:207-11.
1.   Kjaer KW, Hansen L, Eiberg H, Leicht P, Opitz JM, Tommerup N. Novel Connexin 43 (GJA1) mutation causes oculo-dento-digital dysplasia with curly hair. Am J Med Genet A. 2004;127:152-7.

Presentations related to WJC

European Human Genetics Conference 2009 (ESHG 2009)
Wienna, Austria, May 23, 2009
8.   Hansen L, Riis AK, Hove H, Lauridsen E, Eiberg H, Kreiborg S. Analysis of RUNX2 in a Danish cohort of cleidocranial dysplasia patients revealed two large chromosomal deletions and 14 pathogenic point mutations.
Stockholm, June 11, 2008
7.   Rendtorff ND, LOdahl M, Hansen L, Chapka E, Bitner-Glindzicz M, Welch KO, Möller C, Lindholm S, Eriksson K, Ensgård S, Tranebjærg L. WFS1 mutations and phenotypic heterogeneity in 12 families with WFS1 related disease.
NOK 2006 XXXVII Nordic Congress of Ophthalmology
Copenhagen, Denmark - June 17-20, 2006, June 17, 2006
6.   Hansen L, Rosenberg T, Eiberg H, Kjær K. Mutation identification in Danish families with congenital cataract. Acta Ophthalmologica Scandinavica, June 2006 - Vol. 84 Issue s238 Page 4-122.
Oral presentations
5.   Hansen L, Rosenberg T, Thygesen J, Bek T, Kreiborg S, Engenheiro E, Tommerup N. The genetic background for Rieger syndrome, Rieger’s anomaly and Peters’ anomaly – a complex etiology with complex genetics. Acta Ophthalmologica Scandinavica, June 2006 - Vol. 84 Issue s238 Page 4-122.

22.4.39, March 30, 2005
4.   Hansen L, Rosenberg T, Eiberg H, Kjær K. Mutation identification in Danish families with congenital cataract. Acta Ophthalmologica Scandinavica, 84, s238, Page 120-122, Jun 2006.
European Human Genetics Conference 2004
Münich, June 11, 2004
3.PDF  Hansen L, Tranebjærg L, Eiberg H, Rosenberg T. Molecular characterization of WFS1 in five Danish patients with Wolfram syndrome.
European Human Genetics Conference 2003
Birmingham, England, May 02, 2003
2.PDF  Kjaer KW, Christensen KS, Hansen L, Tommerup N. Second case of inherited Laurin-Sandrow Syndrome (LSS)?.
1.PDF  Hansen L, Wu Q, Tommerup N. Characterisation of the human Iroquois (IRX) homeobox genes: proposal for a systematic nomenclature.

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