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Asli Silahtaroglu

Asli Silahtaroglu

Research Associate Professor / Forskningslektor

Development of Locked Nucleic Acid (LNA) as probes for in situ hybridization on metaphase chromosomes, interphase nuclei and tissue sections Mapping disease-associated translocation-breakpoints and isolating genes. Developing and assesing techniques for high resolution in situ hybridization for revealing chromatin sturucture and genome organization (like the gap regions or regions of segmental duplications)


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Publications related to WJC

15.   Clemmensen SN, Bohr CT, Rørvig S, Glenthøj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N. Olfactomedin 4 defines a subset of human neutrophils. J Leukoc Biol. 2012;91:495-500.
14.   Silahtaroglu AN. LNA-FISH for Detection of MicroRNAs in Frozen Sections. Methods Mol Biol. 2010;659:165-71.
13.   Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, De Strooper B. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet. 2010;19:3959-69.
12.   Dyrskjøt L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhøi BP, Kjems J, Borre M, Orntoft TF. Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Res. 2009;69:4851-60.
11.   Schepeler T, Reinert JT, Ostenfeld MS, Christensen LL, Silahtaroglu AN, Dyrskjøt L, Wiuf C, Sørensen FJ, Kruhøffer M, Laurberg S, Kauppinen S, Ørntoft TF, Andersen CL. Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Research. 2008;68:6416-24.
10.   Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimers disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008;105:6415-20.
9.   Stenvang J, Silahtaroglu AN, Lindow M, Elmen J, Kauppinen S. The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol. 2008;18:89-102.
8.PDF  Silahtaroglu AN, Nolting D, Dyrskjøt L, Berezikov E, Møller M, Tommerup N, Kauppinen S. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc. 2007;2:2520-8.
7.   Silahtaroglu AN, Jensen LR, Harboe TL, Horn P, Bendixen C, Tommerup N, Tumer Z. Sequencing and mapping of the porcine CCS gene. Anim Genet. 2004;35:353-4.
6.   Silahtaroglu AN, Tommerup N, Vissing H. FISHing with locked nucleic acids (LNA): evaluation of different LNA/DNA mixmers. Mol Cell Probes. 2003;17:165-9.
5.   Poulsen TS, Silahtaroglu AN, Gisselo CG, Tommerup N, Johnsen HE. Detection of illegitimate rearrangements within the immunoglobulin light chain loci in B cell malignancies using end sequenced probes. Leukemia. 2002;16:2148-55.
4.   Poulsen TS, Silahtaroglu AN. Detection of illegitimate rearrangements within the immunoglobulin light chain loci in B cell malignancies using end-sequenced probes. Leukemia. 2002;16:2156-8.
3.   Hacihanefioglu S, Guven GS, Deviren A, Silahtaroglu AN, Yosunvkaya Fenerci E, Ozkilic A, Yuksel A. Trisomy 9p syndrome in two brothers: with new clinical findings and review of the literature. Genet Couns. 2002;13:41-8.
2.   Silahtaroglu AN, Brondum-Nielsen K, Gredal O, Werdelin L, Panas M, Petersen MB, Tommerup N, Tumer Z. Human CCS gene: genomic organization and exclusion as a candidate for amyotrophic lateral sclerosis (ALS). BMC Genetics. 2002;3:5 (doi:10.1186/1471-2156-3-5).
1.   Poulsen TS, Silahtaroglu AN, Gisselo CG, Gaarsdal E, Rasmussen T, Tommerup N, Johnsen HE. Detection of illegitimate rearrangement within the immunoglobulin locus on 14q32.3 in B-cell malignancies using end-sequenced probes. Genes Chromosomes Cancer. 2001;32:265-74.

Presentations related to WJC

71st CSHL SYMPOSIUM: Regulatory RNAs
Cold Spring Harbor Laboratory, May 31, 2006
2.   Bak M, Silahtaroglu AN, Christensen M, Møller M, Skryabin B, Kloosterman W, Nolting D, Rath MF, Brosius J, Plasterk R, Tommerup N, Kauppinen S. microRNAs in the mammalian brain.
European Human Genetics Conference 2002
Strasbourg, France, May 24, 2002
1.   Silahtaroglu AN, Poulsen TS, Gisselø CG, Tommerup N, Johnsen HE. Detection of illegitimate rearrangements within the immunoglobulin light chain loci in B-cell malignancies. Eur J Hum Genet 2002:10(supp);106 (poster 0152).

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