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Center director:
Prof. Niels Tommerup
tommerup@imbg.ku.dk







Centre contact information

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Mette Christensen

Ph.d. student / Ph.d. studerende

The role of microRNAs in brain development and disorders

MicroRNAs are short endogenous RNAs that act as post-transcriptional regulators of gene expression. Despite recent advances, our knowledge about their biological roles is still limited. This PhD project aims at unraveling the role of microRNA-based gene regulation in mammalian brain development and disorders, with special emphasis on Alzheimer┤s disease. The project will ask the following fundamental questions: (i) which microRNAs are involved in neuronal differentiation, brain development and Alzheimer┤s disease, (ii) when and where are they expressed, (iii) what are their biological roles and (iv) how do they function? LNA microarrays will be used to identify candidate microRNAs involved in neuronal and brain development and their spatiotemporal expression patterns will be determined by LNA-based in situ hybridization. The experimental data will be combined with advanced bioinformatic searches and database mining to identify candidate target genes for neuronal microRNAs, followed by functional studies of miRNA-based gene regulation using genetics and biochemistry.

Present address:

  • University of Heidelberg, Interdiciplinary Center for Neurosciences (IZN), SFB488 Junior Group A.G. Schratt, Im Neuenheimer Feld 345, 1OG R160, 69120, Heidelberg, Germany

    Emailmch@imbg.ku.dk
    Present AddressUniversity of Heidelberg, Interdiciplinary Center for Neurosciences (IZN), SFB488 Junior Group A.G

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    Publications related to WJC

    6.   Christensen M, Larsen LA, Kauppinen S, Schratt G. Recombinant Adeno-Associated Virus-Mediated microRNA Delivery into the Postnatal Mouse Brain Reveals a Role for miR-134 in Dendritogenesis in Vivo. Front Neural Circuits. 2010;3:16.
     
    5.   Christensen M, Schratt GM. microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases. Neuroscience Letters 2009;466:55-62.
     
    4.   Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, HŘbel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol. 2009;11:705-16.
     
    3.   ElmÚn J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjńrn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 2008;36:1153-62.
     
    2.   Bak M, Silahtaroglu A, M°ller M, Christensen M, Rath MF, Skryabin B, Tommerup N, Kauppinen S. MicroRNA expression in the adult mouse central nervous system. RNA. 2008;14:432-44.
     
    1.   Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S, Cole CN. Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res. 2007;67:11612-20.
     

    Presentations related to WJC

    71st CSHL SYMPOSIUM: Regulatory RNAs
    Cold Spring Harbor Laboratory, May 31, 2006
    Posters
    2.   Bak M, Silahtaroglu AN, Christensen M, M°ller M, Skryabin B, Kloosterman W, Nolting D, Rath MF, Brosius J, Plasterk R, Tommerup N, Kauppinen S. microRNAs in the mammalian brain.
     
    Keystone Symposia: RNAi and Related Pathways
    Vancouver, British Columbia, Canada, January 26, 2006
    Posters
    1.   Christensen M, Bak M, Silahatroglu A, Kloostermann W, Skryapin B, Nolting D, N°rrem°lle A, Lassen A-C, Hasholt L, Brosius J, Tommerup N, Plasterk R, Kauppinen S. miRNAs in mammalian brain.
     

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