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Center director:
Prof. Niels Tommerup

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Wilhelm Johannsen Centre for Functional Genome Research was established in 2001 by a grant from the Danish National Research Foundation and support from the University of Copenhagen. Following an international review and site visit in 2005, the granting period was extended to 30 June 2011. The center is hosted by the Department of Cellular and Molecular Medicine at the Panum Institute, University of Copenhagen. The aim of the centre is to contribute to the functional characterization of the human genome by identification of novel human disease genes, of novel genetic entities and of novel genetic mechanisms by systematic mapping and characterization of chromosomal and genomic rearrangements associated with abnormal and normal phenotypes.

Main research themes includes:

Mapping and functional characterization of structural chromosomal and genomic rearrangements (translocations, inversions, copy number variations) in relation to protein-coding genes; non-coding RNA genes (ncRNA), including microRNAs; long range position effects and epigenetic modifications. Specific diseases studied includes: Brain disorders as models for the use of comorbidity in genetic research (dyslexia, epilepsy, mental retardation, autism, sleep disorders, and others); congential heart defects and limb defects as developmental models; Identification of disease genes in general using systems biology approaches.

Sidste nyt (in Danish)

System Biologi: Integrering af Fænomet med Interaktomet forudsiger nye sygdomsgener
MicroRNA - nye regulatoriske netværk med kobling til medfødte misdannelser og kromosomfejl
Omtale af WJC projekt om ordblindhed i lærernes fagblad
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